General

Cell Line

hPSCreg name SCVIi111-A
Cite as:
SCVIi111-A (RRID:CVCL_D6LT)
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
NUIGi005-A
(LQTS004C7, LQT004C7)
Donor diseases:
Long QT Syndrome 1
NUIGi005-B
(LQTS004C9, LQT004C9)
Donor diseases:
Long QT Syndrome 1
NUIGi005-C
(LQTS004Cx, LQT004Cx)
Donor diseases:
Long QT Syndrome 1
NUIGi008-A
(LQTS007C1)
Donor diseases:
Long QT Syndrome 1
NUIGi008-B
(LQTS007C2)
Donor diseases:
Long QT Syndrome 1
NUIGi008-C
(LQTS007Cx)
Donor diseases:
Long QT Syndrome 1
NUIGi009-A
(LQTS008C1)
Donor diseases:
Long QT Syndrome 1
NUIGi009-B
(LQTS008C6)
Donor diseases:
Long QT Syndrome 1
NUIGi009-C
(LQTS008Cx)
Donor diseases:
Long QT Syndrome 1
NUIGi011-A
(LQTS010C3)
Donor diseases:
Long QT Syndrome 1
NUIGi011-B
(LQTS010C4)
Donor diseases:
Long QT Syndrome 1
NUIGi011-C
(LQTS010Cx)
Donor diseases:
Long QT Syndrome 1
TAUi006-A
(UTA.00102.LQT1)
Donor's gene variants:
KCNQ1 – potassium voltage-gated channel subfamily Q member 1
Donor diseases:
Long QT Syndrome 1
TAUi006-B
(UTA.00118.LQT1)
Donor's gene variants:
KCNQ1 – potassium voltage-gated channel subfamily Q member 1
Donor diseases:
Long QT Syndrome 1
TAUi007-A
(UTA.00208.LQT1)
Donor's gene variants:
KCNQ1 – potassium voltage-gated channel subfamily Q member 1
Donor diseases:
Long QT Syndrome 1
TAUi007-B
(UTA.00211.LQT1)
Donor's gene variants:
KCNQ1 – potassium voltage-gated channel subfamily Q member 1
Donor diseases:
Long QT Syndrome 1
NUIGi006-A
(LQTS005C2, LQT005C2)
Donor diseases:
Long QT Syndrome 1
NUIGi006-B
(LQTS005C4, LQT005C4)
Donor diseases:
Long QT Syndrome 1
NUIGi006-C
(LQTS005Cx, LQT005Cx)
Donor diseases:
Long QT Syndrome 1
NUIGi007-A
(LQTS006C6, LQT006C6)
Donor diseases:
Long QT Syndrome 1
NUIGi007-B
(LQTS006C8, LQT006C8)
Donor diseases:
Long QT Syndrome 1
NUIGi010-A
(LQTS009C2)
Donor diseases:
Long QT Syndrome 1
NUIGi010-B
(LQTS009C3)
Donor diseases:
Long QT Syndrome 1
NUIGi010-C
(LQTS009Cx)
Donor diseases:
Long QT Syndrome 1
LUMCi039-A
(LQT1-1781G/A hiPSC, LUMC0021iKCNQ-30)
Donor's gene variants:
KCNQ1, KCNQ1
Donor diseases:
Long QT Syndrome 1
INSRMi021-A
(PC177 3c14)
Donor diseases:
myofibrillar myopathy 1
PUMCHi002-A
(20180908R-AE3, PUMCH-IRC)
Donor diseases:
Restrictive Cardiomyopathy
ITXi004-A
(MS381)
Donor diseases:
Long QT Syndrome
FAMRCi006-A
(LMNA T3)
Donor's gene variants:
LMNA
Donor diseases:
Emery-Dreifuss Muscular Dystrophy
Dilated Cardiomyopathy
FAMRCi006-B
(LMNA T4)
Donor's gene variants:
LMNA
Donor diseases:
Emery-Dreifuss Muscular Dystrophy
Dilated Cardiomyopathy
UKKi031-A
(NP0138-8B)
Donor's gene variants:
TNNT2
Donor diseases:
Rare hypertrophic cardiomyopathy
UKKi031-B
(NP0138-19E)
Donor's gene variants:
TNNT2
Donor diseases:
Rare hypertrophic cardiomyopathy
ZJSHi001-A
(ZJSHi-KCNB1)
Donor's gene variants:
KCNB1
Donor diseases:
developmental and epileptic encephalopathy, 26
UKKi031-C
(NP0138-31B)
Donor's gene variants:
TNNT2
Donor diseases:
Rare hypertrophic cardiomyopathy
USFi003-A
(1AB1)
Donor diseases:
Dilated Cardiomyopathy
YUCMi022-A
(hiPSC-KCNH2_G53S)
Donor diseases:
Long QT Syndrome
SCTCi011-A
(IPS18-00072)
Donor diseases:
age-related macular degeneration
CMCi009-A
(CMC-BHD-001)
Donor's gene variants:
FLCN
Donor diseases:
Birt-Hogg-Dube Syndrome
SCTCi015-A
(IPS19-00051)
Donor diseases:
Age-Related Macular Degeneration
FAMRCi010-A
(RCMP48)
Donor's gene variants:
FLNC
Donor diseases:
Restrictive Cardiomyopathy
UKKi025-A
(NP0135-1)
Donor's gene variants:
MYH7
Donor diseases:
Rare hypertrophic cardiomyopathy
Last update 22nd March 2024
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Provider

Generator Stanford Cardiovascular Institute (SCVI)

External Databases

BioSamples SAMEA115429405
Cellosaurus CVCL_D6LT

General Information

* Is the cell line readily obtainable for third parties?
Yes
Research use: allowed
Clinical use: not allowed
Commercial use: not allowed

Donor Information

General Donor Information

Sex female

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
Synonyms
  • Romano-Ward Syndrome
  • Long QT Syndrome 1
  • LQT1

External Databases (Donor)

BioSamples SAMEA115429406

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? No
Provide contact information of the holder of the original Donor Information Sheet: yanzhuge@stanford.edu
Do you (Depositor/Provider) hold the original Donor Consent Form? Yes
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. pseudonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No
How may genetic information associated with the cell line be accessed? Controlled Access
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? No
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General

Source cell type
A peripheral blood cell with a single nucleus. This category includes lymphocytes and monocytes.
Synonyms
  • PERIPHERAL BLOOD MONONUCLEAR CELL
  • Peripheral Blood Mononuclear Cell
  • PBMC

Reprogramming method

Vector type Non-integrating
Vector Sendai virus

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Medium Essential 8™

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR Flow Cytometry Enzymatic Assay Expression Profiles
SOX2
Yes
NANOG
Yes
POU5F1 (OCT-4)
Yes
Differentiation Potency
Endoderm
Ont Id: UBERON_0000925
In vitro directed differentiation
Mesoderm
Ont Id: UBERON_0000926
In vitro directed differentiation
Ectoderm
Ont Id: UBERON_0000924
In vitro directed differentiation

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Yes
Female normal karyotype

Other Genotyping (Cell Line)