UPITTi002-A-1

Registration Summary:

A P E C

PLN-R9C

The cell line is not submitted yet.

(only basic data is shown)

General

Cell Line
hPSCreg name	UPITTi002-A-1
Cite as:	UPITTi002-A-1 (RRID:CVCL_C0EU)
Alternative name(s)	PLN-R9C
Cell line type	Human induced pluripotent stem cell (hiPSC)
Similar lines	No similar lines found.
Last update	17th July 2021
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Provider
Generator	University of Pittsburgh (UPITT)
External Databases
Cellosaurus	CVCL_C0EU
Wikidata	Q112930525
General Information
Publications	Barndt RJ et al. Modeling of dilated cardiomyopathy by establishment of isogenic human iPSC lines carrying phospholamban C25T (R9C) mutation (UPITTi002-A-1) using CRISPR/Cas9 editing. Stem cell research. 2021 Oct;56:102544. Dong M et al. CRISPR/CAS9: A promising approach for the research and treatment of cardiovascular diseases. Pharmacological research. 2022 Nov;185:106480. Barndt RJ et al. Metabolic Maturation Exaggerates Abnormal Calcium Handling in a Lamp2 Knockout Human Pluripotent Stem Cell-Derived Cardiomyocyte Model of Danon Disease. Biomolecules. 2022 Dec 29;13(1). Nandy Krittika et al. Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression. Scientific Reports. 2023-12-11. Rahman S.M.. Opportunities and challenges for human microphysiological systems in drug development. ALTEX. 2024-00-00. Munshi Ingita Dey et al. Recent development in CRISPR-Cas systems for cardiac disease. Progress in Molecular Biology and Translational Science. 2025-00-00. Cavazza Alessia et al. Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group. Molecular Therapy Nucleic Acids. 2025-03-00. Gerritse Merel et al. Characteristics and pharmacological responsiveness in hiPSC models of inherited cardiomyopathy. Pharmacology & Therapeutics. 2025-08-00.
Subclone of	UPITTi002-A

hIPSC Derivation

General
The source cell information can be found in the parental cell line UPITTi002-A.