Establishment of a human induced pluripotent stem cell line, KSCBi015-A, from a long QT syndrome type 1 patient harboring a KCNQ1 mutation
Summary
Long QT syndrome type 1 (LQT1) is a genetic cardiac disorder caused by a loss-of-function mutation in the KCNQ1 gene. In this study, we generated a human induced stem cell line (KSCBi015-A) from an LQT1 patient with a heterozygous mutation located in the KCNQ1 gene, c.569G > A. The KSCBi015-A cell line showed the maintenance of stem cell-like morphology, normal karyotype, and pluripotency, and could differentiate into three germ layers in vitro. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Lee Y, Park H, Kyung Koo S, Kim JH |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 Oct;56:102521 |
| PubMed | 34509919 |
| DOI | 10.1016/j.scr.2021.102521 |