Establishment of an induced pluripotent stem cell line ZZUi003-A from a 65-year-old male with sporadic Parkinson's disease


Skin fibroblasts were collected from a 65-year-old male patient with sporadic Parkinson's disease. Induced pluripotent stem cells were reprogrammed with human reprogramming factors (KMOSL) using the messenger RNA reprogramming protocol. The transgene-free iPSC line showed pluripotency, displayed normal karyotype, and could form embryoid bodies in vitro and differentiate into all 3 germ layers in vivo. This iPSC line can be a useful cellular model for studying the mechanism of Parkinson's disease. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Zheng X, Zhu Z, Chen K, Guo S, Liu T, Liu H
Journal Stem cell research
Publication Date 2017 Aug;23:119-121
PubMed 28925360
DOI 10.1016/j.scr.2017.07.004

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