Generation of an induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient with a pathogenic LRP10/c.688C > T(p.Arg230Trp) mutation
Summary
Parkinson's disease (PD) is a highly prevalent and severe neurodegenerative disease that affects more than 10 million individuals worldwide. Pathogenic mutations in LRP10 have been associated with autosomal dominant PD. Here, we report an induced pluripotent stem cell (iPSC) line generated from a PD patient harboring the LRP10 c.688C > T (p.Arg230Trp) variant. Skin fibroblasts from the PD patient were successfully reprogrammed into iPSCs that expressed pluripotency markers, a normal karyotype, and the capacity to differentiate into the three germ layers in vivo. This iPSC line is a potential resource for studying the pathogenic mechanisms of PD. Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Wang Y, Wei C, Liu Y, Lu X, Wang W, Song N, Zhang W, Xu J, Zhang W, Han F |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Jun;77:103359 |
| PubMed | 38460235 |
| DOI | 10.1016/j.scr.2024.103359 |