Generation of a human induced pluripotent stem cell line (INNDSUi003-A) derived from patient with Becker muscular dystrophy (BMD)
Summary
Becker muscular dystrophy (BMD), an X-linked recessive disorder caused of mutation in the dystrophin gene, is characterized by progressive muscle degeneration and proximal muscle weakness. We generated a human induced pluripotent stem cell (hiPSC) line from the fibroblasts isolated from patient with BMD by non-integrating reprogramming methods. The iPSC line highly expresses pluripotency markers, displays the normal karyotype and is able to differentiate into the three germ layers in vitro. The iPSC line will be a useful tool to study the pathogenesis of BMD and for drug screening. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Ji X, Wang Y, Sun P, Wang D, Sun X, Zhang R, Xu J, Li W, Liu F, Yan C |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Jul;62:102794 |
| PubMed | 35526387 |
| DOI | 10.1016/j.scr.2022.102794 |