Changes in metabolite profiles in the cerebrospinal fluid and in human neuronal cells upon tick-borne encephalitis virus infection
Summary
Our findings reveal that the neurological disease outcome of TBEV infection is associated with specific and dynamic metabolic signatures in the cerebrospinal fluid. We describe a new in vitro model for in-depth studies of TBEV-induced neuropathogenesis, in which the depletion of identified metabolites limits virus infection. Collectively, this reveals new biomarkers that can differentiate and predict TBEV-associated neurological disease. Additionally, we have identified novel therapeutic targets with the potential to significantly improve patient outcomes and deepen our understanding of TBEV pathogenesis. © 2025. The Author(s).
| Authors | Suyama S, Boxall S, Grace B, Fořtová A, Pychova M, Krbkova L, Mandal R, Wishart D, Griffin DE, Růžek D, Goonawardane N |
|---|---|
| Journal | Journal of neuroinflammation |
| Publication Date | 2025 Jun 14;22(1):157 |
| PubMed | 40517242 |
| PubMed Central | PMC12166563 |
| DOI | 10.1186/s12974-025-03478-4 |