Cell Line

hPSCreg Name
Cell line type Human induced pluripotent stem cell (hiPSC)
Last update 15th August 2022
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Generator dongmei ji (AHMU)
Owner dongmei ji (AHMU)
Derivation country China

External Databases

BioSamples SAMEA110176023
CLO CLO_0103909
Cellosaurus CVCL_C1SF
Wikidata Q114310539

General Information

* Is the cell line readily obtainable for third parties?

Donor Information

General Donor Information

Sex male
Ethnicity Asian (China)

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
Leber hereditary optic neuropathy
Leber optic atrophy, also known as Leber hereditary optic neuropathy (LHON), can be caused by mutation in multiple genes encoded by the mitochondrial genome (mtDNA).
Disease associated phenotypes
  • selective degeneration of retinal ganglion cells (RGCs) and optic atrophy
  • LHON
Non-disease associated phenotypes
  • NON
Family history The proband was suffered from hereditary optic neuropathy. The proband's grandmother, Mother, sister and uncle all have mitochondria 3635G>A mutation. Theproband's grandmother, both uncles have clinical manifestation.
Is the medical history available upon request? The proband was suffered from hereditary optic neuropathy when he was child.
Is clinical information available? The probandharbours homoplasmic m.3635G>A mutations and has clinical symptoms.

Karyotyping (Donor)

Has the donor karyotype been analysed?

Other Genotyping (Donor)

Is there genome-wide genotyping or functional data available?

External Databases (Donor)

BioSamples SAMEA110176024


Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? No
Provide contact information of the holder of the original Donor Information Sheet: Holder:Dongmei Ji,Tel:008615155158242
Do you (Depositor/Provider) hold the original Donor Consent Form? Yes
Alternatives to consent are available? No
Confirm that consent was obtained by a qualified professional Yes
Has the donor been informed about how her/his data will be protected? Yes
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. anonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent permit unforeseen future research, without further consent? No
Does the consent permit uses of donated embryo/tissue or derived cell line intended for clinical treatment or human applications? No
Does consent expressly prevent development of commercial products? Yes
Does consent expressly prevent financial gain from any use of the donated embryo/tissue, including any product made from it? Yes
Does consent expressly permit storage of donated embryo/tissue for an unlimited time? Yes
Does consent expressly permit storage of cells derived from the donated embryo/tissue for an unlimited time? Yes
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No
How may genetic information associated with the cell line be accessed? Controlled Access
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? the Ethics Committee of the Anhui Medical University (Hefei, China; Approval No. 20190190).
Approval number Approval No. 20190190
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation


Source cell type
Derived Peripheral Blood Mononuclear Cell
Mononuclear cells collected from peripheral blood.
  • Peripheral Blood Mononuclear cells
  • Derived Peripheral Blood Mononuclear Cell
Source cell origin
A liquid tissue; its major function is to transport oxygen throughout the body. It also supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection. Several hormones also travel in the blood.
  • Reticuloendothelial System, Blood
  • Peripheral Blood
  • peripheral blood
  • blood
  • Blood
  • Whole Blood
show more synonyms
Passage number reprogrammed 6

Reprogramming method

Vector type Integrating
Vector Plasmid
Is the used vector excisable?
Absence of reprogramming vector(s)?
Reprogramming vectors silenced?
Methods used

Vector free reprogramming


Derived under xeno-free conditions
Derived under GMP?
Available as clinical grade?

Culture Conditions

Surface coating Matrigel/Geltrex
Medium Other medium:
Base medium:
Main protein source:
Serum concentration: %
Has Rock inhibitor (Y27632) been used at passage previously with this cell line?
Has Rock inhibitor (Y27632) been used at cryo previously with this cell line?
Has Rock inhibitor (Y27632) been used at thaw previously with this cell line?


Analysis of Undifferentiated Cells
Marker Present Absent
Morphology pictures
Differentiation Potency
Ont Id: UBERON_0000925
In vivo teratoma
Ont Id: UBERON_0000926
In vivo teratoma
Cartilage Element
Ont Id: UBERON_0007844
In vivo teratoma
Ont Id: UBERON_0000924
In vivo teratoma
Ont Id: CL_0000540
In vivo teratoma


Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Passage number: 6
Karyotyping method: G-Banding

Other Genotyping (Cell Line)