Generation of an induced pluripotent stem cell line, FJMUUHi001-A, from a hereditary Parkinson's disease patient with homozygous mutation of c.189dupA in PARK7


PARK7 mutations are accountable for the inherited Parkinson's disease. An induced pluripotent stem cell (iPSC) line FJMUUHi001-A was generated by expressing five reprogramming factors, OCT3/4, SOX2, c-MYC, KLF4 and BCL-XL, in peripheral blood mononuclear cells from a 32-year old patient carrying a homozygous mutation of c.189dupA in PARK7. The iPSCs with a normal karyotype had the abilities to differentiate into three germ layers and expressed pluripotency markers without detectable residual plasmids. The cell line FJMUUHi001-A carrying the truncating protein PARK7 could be a useful tool to help comprehend the function of PARK7 in the iPSCs and differentiated cells from them. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Chen ZT, Zhao ZH, Chen LN, Fan F, Cai GE, Weng HD, Wang YQ, Liao LM, Chen XC, Huang E, Ye QY
Journal Stem cell research
Publication Date 2021 Mar;51:102175
PubMed 33485186
DOI 10.1016/j.scr.2021.102175

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