Chondrocytes differentiated from human induced pluripotent stem cells: Response to ionizing radiation


The chondrocyte-like cells derived from hiPSC demonstrated features characteristic of both mature chondrocytes and "parental" hiPSCs. The main difference between hiPSC-derived chondrocytes and hiPSCs and mature chondrocytes appears to be the more efficient DDR mechanism of hiPSC-DCHs. The unique properties of these cells suggest that they could potentially be used safely in regenerative medicine if these preliminary findings are confirmed in future studies.

Authors Stelcer E, Kulcenty K, Suchorska WM
Journal PloS one
Publication Date 2018;13(10):e0205691
PubMed 30352062
PubMed Central PMC6198947
DOI 10.1371/journal.pone.0205691

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