Generation of an induced pluripotent stem cell line (SIAISi009-A) from a 60-year-old Chinese Han female with mild cognitive impairment (MCI) having two copies of APOE4/4 allele
Summary
Induced pluripotent stem cells play vitally essential roles in regenerative medicines for disease modeling and drug screening. Here, we successfully generated an iPSC line from PBMC of a 60-year-old female with mild cognitive impairment in an APOE 4/4 background to better understand studies relating to MCI and other cognitive diseases. In the newly-developed hiPSC line SIAISi009-A, all pluripotent markers were well expressed. Moreover, cells displayed a normal karyotype and have differentiation potential proven by in vitro trilineage differentiation method. Copyright © 2021. Published by Elsevier B.V.
| Authors | Guo J, Di W, Zhang W, Dai Q, Zhao J, Deng Y, Wang Y |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 Mar;51:102198 |
| PubMed | 33524675 |
| DOI | 10.1016/j.scr.2021.102198 |