A single-cell transcriptomic atlas of human lens epithelium: identification and functional insights into lens stem/progenitor cells
Summary
This study identified four subclasses of LECs within the human lens epithelium that follow a progressive staged development pathway from progenitor cells to mature LECs. TOP2A can serve as a biomarker for TAC in the lens, and LPLCs sustain their dedifferentiated state by expressing ID1. The aging process does not appear to alter cell population demographics, but significant alteration in gene expression profile is observed. Moreover, PTN signaling emerges as a crucial factor in lens homeostasis and represents a potential target for cataract drug development. © 2025. The Author(s).
| Authors | Gu Y, Chen L, Chen S, Wu Y, Hao S, Sheng F, Yuan J, Qin Z, Wu D, Han Y, Yao Z, Chen Z, Wormstone IM, Yu Y, Qian J, Fu Q, Yao K |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2025 Jul 1;16(1):333 |
| PubMed | 40598599 |
| PubMed Central | PMC12211975 |
| DOI | 10.1186/s13287-025-04436-w |