Generation of an induced pluripotent stem cell line SDQLCHi026-A from a hereditary tyrosinemia type I patient carrying compound heterozygote mutations in FAH gene

Summary

Here we describe the generation of induced pluripotent stem cells (iPSCs) from a patient diagnosed as hereditary tyrosinemia type I (HT1) caused by FAH gene mutation. Induced pluripotent stem cells (iPSCs) were developed using non-integrating episomal vectors containing OCT4, SOX2, KLF4, BCL-XL and MYC. The established iPSC line (SDQLCHi026-A) displayed pluripotent cell morphology, high expression levels of pluripotency markers, differentiation potential in vitro, normal karyotype, and remaining the original FAH gene mutation. Copyright © 2021. Published by Elsevier B.V.

Authors Zhang H, Liu C, Ma Y, Lin L, Lv Y, Gao M, Gai Z, Liu Y
Journal Stem cell research
Publication Date 2021 Apr 9;53:102331
PubMed 33882394
DOI 10.1016/j.scr.2021.102331

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