Generation of an induced pluripotent stem cell line from a 39-year-old female patient with severe-to-profound non-syndromic sensorineural hearing loss and a A1555G mutation in the mitochondrial MTRNR1 gene
Summary
Sensorineural hearing loss (SNHL) is a prevalent form of deafness commonly arising from damage to the cochlear sensory hair cells and degeneration of the spiral ganglion neurons. In this study, Sendai virus was used to generate an induced pluripotent stem cell (iPSC) line from a 39-year-old female patient diagnosed with severe-to-profound, non-syndromic SNHL. The patient also carries a A1555G mutation in the mitochondrial 12S ribosome RNA gene (MTRNR1). This iPSC line was verified to express pluripotent markers, possess normal karyotype, harbor the specific mutation and demonstrated the capacity to differentiate into three germ layers. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Hsu YH, Wu YT, Huang CY, Ho MC, Cheng YC, Syu SH, Lu HE, Chen YC, Tsai CL, Lin HC, Wei YH, Hsu YC, Hsieh PCH |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2017 Dec;25:245-249 |
| PubMed | 29174977 |
| DOI | 10.1016/j.scr.2017.10.024 |