Evaluation of 2D and 3D Erythroid Differentiation Protocols Using Sickle Cell Disease and Healthy Donor Induced Pluripotent Stem Cells
Summary
A robust 3D protocol for erythroid differentiation was identified using SCD-iPSCs and comparative analyses; however, the maturation step remains challenging and requires further development.
| Authors | Martins GLS, Nonaka CKV, Rossi EA, de Lima AVR, Adanho CSA, Oliveira MS, Yahouedehou SCMA, de Souza CLEM, Gonçalves MS, Paredes BD, Souza BSF |
|---|---|
| Journal | Cells |
| Publication Date | 2023 Apr 10;12(8) |
| PubMed | 37190030 |
| PubMed Central | PMC10137038 |
| DOI | 10.3390/cells12081121 |