Generation of human induced pluripotent stem cell lines from two patients affected by catecholamine-induced QT prolongation (CIQTP)
Summary
Catecholamine-induced QT prolongation (CIQTP) is an inherited cardiac disease characterized by a normal baseline ECG and a risk of sudden cardiac death by ventricular arrhythmia due to a QT prolongation that only appears during catecholergic stimulation, especially mental stress. Induced pluripotent stem cells (hiPSCs) were generated from peripheral blood mononuclear cells collected from two CIQTP-affected patients from two different families. These two hiPSC lines are a valuable model to study biological alterations due to CIQTP. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Cimarosti B, Canac R, Girardeau A, Arnaud M, Francheteau Q, Probst V, Lemarchand P, Redon R, Gourraud JB, Gaborit N, Lamirault G |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Mar;59:102649 |
| PubMed | 34995842 |
| DOI | 10.1016/j.scr.2021.102649 |