Generation of human induced pluripotent stem cell lines from two patients affected by catecholamine-induced QT prolongation (CIQTP)


Catecholamine-induced QT prolongation (CIQTP) is an inherited cardiac disease characterized by a normal baseline ECG and a risk of sudden cardiac death by ventricular arrhythmia due to a QT prolongation that only appears during catecholergic stimulation, especially mental stress. Induced pluripotent stem cells (hiPSCs) were generated from peripheral blood mononuclear cells collected from two CIQTP-affected patients from two different families. These two hiPSC lines are a valuable model to study biological alterations due to CIQTP. Copyright © 2021. Published by Elsevier B.V.

Authors Cimarosti B, Canac R, Girardeau A, Arnaud M, Francheteau Q, Probst V, Lemarchand P, Redon R, Gourraud JB, Gaborit N, Lamirault G
Journal Stem cell research
Publication Date 2021 Dec 30;59:102649
PubMed 34995842
DOI 10.1016/j.scr.2021.102649

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