Generation of human induced pluripotent stem cell lines from two patients affected by catecholamine-induced QT prolongation (CIQTP)


Catecholamine-induced QT prolongation (CIQTP) is an inherited cardiac disease characterized by a normal baseline ECG and a risk of sudden cardiac death by ventricular arrhythmia due to a QT prolongation that only appears during catecholergic stimulation, especially mental stress. Induced pluripotent stem cells (hiPSCs) were generated from peripheral blood mononuclear cells collected from two CIQTP-affected patients from two different families. These two hiPSC lines are a valuable model to study biological alterations due to CIQTP. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Cimarosti B, Canac R, Girardeau A, Arnaud M, Francheteau Q, Probst V, Lemarchand P, Redon R, Gourraud JB, Gaborit N, Lamirault G
Journal Stem cell research
Publication Date 2022 Mar;59:102649
PubMed 34995842
DOI 10.1016/j.scr.2021.102649

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