Generation of an induced pluripotent stem cell line SYSUi-004-A from a child of microcephaly with TYW1 mutations
Summary
We generated an induced human pluripotent stem cell line from a child with microcephaly carrying compound heterozygous mutations of TYW1 inherited from healthy parents. This iPS cell line showed typical embryonic stem cell-like morphology, expressed pluripotent markers that comparable to human embryonic stem cells. Moreover, these cells have the ability to differentiate into three germ layers and maintain a normal karyotype. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Sun C, Zhou P, Yuan S, Guo R, Zhang Z, Xu Q, Han D, He L, Tang H, Xu K, Hu H, Li N |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 May;45:101783 |
| PubMed | 32279010 |
| DOI | 10.1016/j.scr.2020.101783 |