Generation of an induced pluripotent stem cell line SYSUi-004-A from a child of microcephaly with TYW1 mutations

Summary

We generated an induced human pluripotent stem cell line from a child with microcephaly carrying compound heterozygous mutations of TYW1 inherited from healthy parents. This iPS cell line showed typical embryonic stem cell-like morphology, expressed pluripotent markers that comparable to human embryonic stem cells. Moreover, these cells have the ability to differentiate into three germ layers and maintain a normal karyotype. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Sun C, Zhou P, Yuan S, Guo R, Zhang Z, Xu Q, Han D, He L, Tang H, Xu K, Hu H, Li N
Journal Stem cell research
Publication Date 2020 Apr 7;45:101783
PubMed 32279010
DOI 10.1016/j.scr.2020.101783

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