Generation of an induced pluripotent stem cell line SYSUi-004-A from a child of microcephaly with TYW1 mutations
We generated an induced human pluripotent stem cell line from a child with microcephaly carrying compound heterozygous mutations of TYW1 inherited from healthy parents. This iPS cell line showed typical embryonic stem cell-like morphology, expressed pluripotent markers that comparable to human embryonic stem cells. Moreover, these cells have the ability to differentiate into three germ layers and maintain a normal karyotype. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
|Authors||Sun C, Zhou P, Yuan S, Guo R, Zhang Z, Xu Q, Han D, He L, Tang H, Xu K, Hu H, Li N|
|Journal||Stem cell research|
|Publication Date||2020 May;45:101783|