Establishment of a human iPSC (ZZUNEUi026-A) from a dilated cardiomyopathy patient carrying heterozygous Vinculin (c. 625A > T) mutant
Summary
Dilated cardiomyopathy (DCM) is defined by left ventricular (or biventricular dilation) and systolic dysfunction, which eventually develops into congestive heart failure and arrhythmia. Vinculin is a membrane-associated protein, which functions to transmit contractile force. Defects in vinculin have been reported to be associated with DCM and hypertrophic cardiomyopathy. A human induced pluripotent stem cell (iPSC) line (ZZUNEUi026-A) was generated from a DCM patient carrying heterozygous Vinculin mutant (c.A625 > T; p.Met209 > Leu). The cell line was derived from peripheral blood mononuclear cells by nonintegrative Sendai virus. ZZUNEUi026-A showed pluripotency markers and normal karyotype, and it could differentiate into three germ layers in vitro. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Liu Y, Li X, Zhao X, Dong J, Zhang C, Lin T |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Jul;62:102812 |
| PubMed | 35567849 |
| DOI | 10.1016/j.scr.2022.102812 |