Establishment of an induced pluripotent stem cell line (LBMi001-A) from urine of an oligoteratozoospermic patient with isodicentric chromosome Y harboring intact AZF region
Summary
Isodicentric Y chromosomes [idic(Y)] represent one of the most frequent Y chromosomal aberrations, leading to a wide phenotypic spectrum of abnormal sexual development. This study establishes the first urine-derived induced pluripotent stem cell (iPSC) line from an oligoteratozoospermic patient with isodicentric chromosome Y harboring intact AZF region using non-integrating Sendai virus. The iPSC line retained the isodicentric Y chromosome, expressed pluripotency markers, and displayed capability for differentiation of the three germ layers. This iPSC model holds considerable promise as a powerful tool for elucidating the molecular and cellular mechanisms underlying idic(Y)-associated male infertility. Copyright © 2025. Published by Elsevier B.V.
| Authors | Wu J, Ma Y, Zhang X, Lin Y, Zeng J |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Jul 29;87:103793 |
| PubMed | 40752253 |
| DOI | 10.1016/j.scr.2025.103793 |