Generation of three TTN knock-out human induced pluripotent stem cell lines using CRISPR/Cas9 system

Summary

TTN mutations are the common genetic cause for various types of cardiomyopathies (e.g., dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, and arrhythmogenic right ventricular cardiomyopathy) and skeletal myopathies. Here, we generated three TTN knock-out human induced pluripotent stem cell (iPSC) lines using CRISPR/Cas9 system. These cell lines, which exhibit normal karyotype, typical morphology and pluripotency, could provide useful platform for investigating the role of TTN in associated disorders. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Kang JY, Mun D, Chun Y, Park DS, Kim H, Yun N, Lee SH, Joung B
Journal Stem cell research
Publication Date 2022 Aug 25;64:102901
PubMed 36037555
DOI 10.1016/j.scr.2022.102901

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