Generation of human induced pluripotent stem cell line (WMUi001-A) from a patient with aortic dissection
A human induced pluripotent stem cell (hiPSC) line (WMUi001-A) was generated from the aortic tissue of a 47-year-old donor with aortic dissection and normal blood pressure. Integration-free episomal vector-mediated reprogramming was used for the generation of this iPSC line. The established iPSC line was found to express pluripotency markers, exhibit a differentiation potential in vitro, as well as display a normal karyotype. We further identified that this iPSC line contained a mutation in collagen type IV (COL4A2, R131M), which may serve as a useful tool for the disease modeling of aortic dissection. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
|Authors||Jin P, Wang S, Jiang X, Shan X, Jiang S, Quan Y, Zhang T, Yang J, Zhang H, Ma J, Dong M, Fan J, Fan X, Gong Y, Wang Y|
|Journal||Stem cell research|
|Publication Date||2020 Mar;43:101730|