Generation of human induced pluripotent stem cell line (WMUi001-A) from a patient with aortic dissection


A human induced pluripotent stem cell (hiPSC) line (WMUi001-A) was generated from the aortic tissue of a 47-year-old donor with aortic dissection and normal blood pressure. Integration-free episomal vector-mediated reprogramming was used for the generation of this iPSC line. The established iPSC line was found to express pluripotency markers, exhibit a differentiation potential in vitro, as well as display a normal karyotype. We further identified that this iPSC line contained a mutation in collagen type IV (COL4A2, R131M), which may serve as a useful tool for the disease modeling of aortic dissection. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Jin P, Wang S, Jiang X, Shan X, Jiang S, Quan Y, Zhang T, Yang J, Zhang H, Ma J, Dong M, Fan J, Fan X, Gong Y, Wang Y
Journal Stem cell research
Publication Date 2020 Mar;43:101730
PubMed 32062133
DOI 10.1016/j.scr.2020.101730

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