Comparative analysis of human microglial models for studies of HIV replication and pathogenesis
Summary
MMG and iPSC-MG appear to be viable microglial models that are susceptible to HIV infection and bear more similarities to authentic microglia than two transformed microglia cell lines. The observed differences in HIV replication and particle capture between MMG and iPSC-MG warrant further study.
| Authors | Rai MA, Hammonds J, Pujato M, Mayhew C, Roskin K, Spearman P |
|---|---|
| Journal | Retrovirology |
| Publication Date | 2020 Nov 19;17(1):35 |
| PubMed | 33213476 |
| PubMed Central | PMC7678224 |
| DOI | 10.1186/s12977-020-00544-y |