Metabolism-related gene PDK1 regulates myocardial cell remodeling and its mechanism
Summary
Our study established a PDK1 knockout model under hypoxia that exhibits mitochondrial metabolism dysregulation, elevated oxidative stress, and decreased cell viability. This model is an important tool for understanding the mechanism of hypoxia-induced myocardial apoptosis, elucidating the gene-phenotype relationship of PDK1 deficiency, and providing evidence to mitigate the damage against hypoxia. © 2025. The Author(s).
Authors | Amina S, Wei M, Zhang S, Jiaqi F, Ma S, Abbas MK, Lan F, Jiang H |
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Journal | Stem cell research & therapy |
Publication Date | 2025 Jul 26;16(1):404 |
PubMed | 40713739 |
PubMed Central | PMC12296610 |
DOI | 10.1186/s13287-025-04518-9 |