Metabolism-related gene PDK1 regulates myocardial cell remodeling and its mechanism

Summary

Our study established a PDK1 knockout model under hypoxia that exhibits mitochondrial metabolism dysregulation, elevated oxidative stress, and decreased cell viability. This model is an important tool for understanding the mechanism of hypoxia-induced myocardial apoptosis, elucidating the gene-phenotype relationship of PDK1 deficiency, and providing evidence to mitigate the damage against hypoxia. © 2025. The Author(s).

Authors Amina S, Wei M, Zhang S, Jiaqi F, Ma S, Abbas MK, Lan F, Jiang H
Journal Stem cell research & therapy
Publication Date 2025 Jul 26;16(1):404
PubMed 40713739
PubMed Central PMC12296610
DOI 10.1186/s13287-025-04518-9

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