Generation and characterization of human induced pluripotent stem cell line METUi001-A from a 25-year-old male patient with relapsing-remitting multiple sclerosis


Multiple sclerosis is a chronic disease characterized by inflammation, demyelination, and axonal damage in the central nervous system. Here, we established an induced pluripotent stem cell (iPSC) line METUi001-A from the peripheral blood mononuclear cells of a 25-year-old male individual with clinically diagnosed Relapsing-Remitting Multiple Sclerosis (RRMS) using the integration-free Sendai reprogramming method. We demonstrated that the iPSCs are free of exogenous Sendai reprogramming vectors, have a normal male karyotype, express pluripotency markers, and differentiate into the three germ layers. The iPSC line can serve as a valuable resource to generate cellular model systems to investigate molecular mechanisms underlying RRMS. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Begentas OC, Koc D, Yurtogullari S, Temel M, Akcali KC, Demirkaya S, Kiris E
Journal Stem cell research
Publication Date 2021 May;53:102370
PubMed 34087999
DOI 10.1016/j.scr.2021.102370

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