Generation of a human induced pluripotent stem cell line (MUi010-A) from skin fibroblast of patient carrying a c.2104C>T mutation in MYH9 gene


Mutations in MYH9 gene is one of the major causes of inherited thrombocytopenia resulted from nonfunctional myosin-9 protein. We have generated a human induced pluripotent stem cell line MUi010-A from skin fibroblasts of a patient who had a point mutation c.2104C>T (p.R702C) in the exon 16 of MYH9 gene using a non-integrative reprogramming method. The MUi010-A exhibited embryonic stem cell-like characteristics with consistent pluripotent markers expression, was capable of all three embryonic germ layers differentiation, and had a normal karyotype. Copyright © 2019. Published by Elsevier B.V.

Authors Tangprasittipap A, Jittorntrum B, Kadegasem P, Sasanakul W, Sirachainan N, Kitiyanant N, Hongeng S
Journal Stem cell research
Publication Date 2019 Apr;36:101397
PubMed 30798146
DOI 10.1016/j.scr.2019.101397

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