Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions
Summary
The novel method demonstrates an easy-to-use intermediate-scale bioreactor platform that produces prime macrophages from human iPSCs. These macrophages are functionally active and require no downstream maturation steps, rendering them highly desirable for both therapeutic and non-therapeutic applications. © 2024. The Author(s).
| Authors | Ackermann M, Saleh F, Abdin SM, Rafiei Hashtchin A, Gensch I, Golgath J, Carvalho Oliveira M, Nguyen AHH, Gaedcke S, Fenske A, Jang MS, Jirmo AC, Abeln M, Hansen G, Lachmann N |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2024 Jun 18;15(1):171 |
| PubMed | 38886860 |
| PubMed Central | PMC11184717 |
| DOI | 10.1186/s13287-024-03785-2 |