Generation of induced pluripotent stem cell line LNDWCHi001-A from a patient with early-onset Parkinson's disease carrying the homozygous c.1898C > T (p. A633V) mutation in the PLA2G6 gene
Summary
A variant of the phospholipase A2 group VI gene (PLA2G6, PARK14) has been found to cause early-onset Parkinson's disease (EOPD). In this study, we reprogrammed peripheral blood mononuclear cells from a 39-year-old patient with EOPD carrying a homozygous PLA2G6 mutation c.1898C > T (p. A633V) to generate the human induced pluripotent stem cell line LNDWCHi001-A. This cell line was identified based on pluripotent markers and displayed differentiation capacity, providing an essential model for studying the pathogenesis of EOPD and drug screening. Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Huang J, Jiang Q, Pang D, Yu Y, Cui Y, Li C, Shang H |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Mar;75:103305 |
| PubMed | 38215561 |
| DOI | 10.1016/j.scr.2024.103305 |