Fibroblasts Drive Metabolic Reprogramming in Pacemaker Cardiomyocytes


Fibroblasts drive Aldoc-mediated metabolic reprogramming and rhythmic regulation in SANs. This work details the cellular machinery behind the complex milieu of vertebrate SANs and opens a new direction for future therapy.

Authors Chou PC, Liu CM, Weng CH, Yang KC, Cheng ML, Lin YC, Yang RB, Shyu BC, Shyue SK, Liu JD, Chen SP, Hsiao M, Hu YF
Journal Circulation research
Publication Date 2022 Jun 24;131(1):6-20
PubMed 35611699
DOI 10.1161/circresaha.121.320301

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