Generation and characterization of twelve human induced pluripotent stem cell (iPSC) lines from four familial long QT syndrome type 1 (LQT1) patients carrying KCNQ1 c.1201dupC mutation
In this study, we describe the generation and characterization of induced pluripotent stem cell (iPSC) lines from familial long QT syndrome type 1 (LQT1) patients carrying the KCNQ1 c.1201dupC (p.Arg401fs) frame shift mutation by using non-integrational Sendai reprogramming method. The patient-specific iPSC lines harboring the c.1201dupC mutation on KCNQ1 gene expressed pluripotency markers and had the capacity to differentiate into three germ layers. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
|Authors||Ge N, Liu M, Ding Y, Krawczyk J, McInerney V, Galvin J, Shen S, Prendiville T, O'Brien T|
|Journal||Stem cell research|
|Publication Date||2019 Dec;41:101650|