Generation and characterization of twelve human induced pluripotent stem cell (iPSC) lines from four familial long QT syndrome type 1 (LQT1) patients carrying KCNQ1 c.1201dupC mutation
Summary
In this study, we describe the generation and characterization of induced pluripotent stem cell (iPSC) lines from familial long QT syndrome type 1 (LQT1) patients carrying the KCNQ1 c.1201dupC (p.Arg401fs) frame shift mutation by using non-integrational Sendai reprogramming method. The patient-specific iPSC lines harboring the c.1201dupC mutation on KCNQ1 gene expressed pluripotency markers and had the capacity to differentiate into three germ layers. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Ge N, Liu M, Ding Y, Krawczyk J, McInerney V, Galvin J, Shen S, Prendiville T, O'Brien T |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2019 Dec;41:101650 |
| PubMed | 31765965 |
| DOI | 10.1016/j.scr.2019.101650 |