Derivation of clinical-grade HLA-homozygous induced pluripotent stem cell line UNIONi001-A from umbilical cord blood of a Han Chinese male neonate
Summary
The clinical-grade iPSC line UNIONi001-A is derived from HLA-homozygous (HLAh) umbilical cord blood mononuclear cells (CBMCs) of a healthy Han Chinese male neonate. Cells were reprogrammed using episomal plasmids with OCT3/4, SOX2, KLF4, c-MYC and BCL-XL. The iPSCs exhibited typical pluripotent stem cell morphology, expressed pluripotency markers, maintained a normal karyotype, and could differentiate into three germ layers, making them suitable for cell therapy research and clinical use. Copyright © 2025 Union Stem Cell Genetic Engineering Co., Ltd. Published by Elsevier B.V. All rights reserved.
| Authors | Shi X, Zhang Q, Cui L, Jia Y, Zhang J, Zhang L, Hou R, Yang W, Du W, Zhang Y |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Oct;88:103818 |
| PubMed | 40857797 |
| DOI | 10.1016/j.scr.2025.103818 |