Heterozygous LMNA mutation-carrying iPSC lines from three cardiac laminopathy patients


LMNA-related dilated cardiomyopathy (LMNA-DCM) is caused by pathogenic variants in the LMNA gene and is characterized by left ventricular chamber enlargement, reduced systolic function, and arrhythmia. Here, we generated three human induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMCs) of three DCM patients carrying the same single heterozygous mutation, c.398 G > A, in LMNA. All lines exhibited normal iPSC morphology, expressed high levels of pluripotency markers, showed normal karyotypes, and could differentiate into the three germ layers. These patient-specific iPSC lines can serve as invaluable tools to model in vitro pathological mechanisms of LMNA-DCM. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Cho S, Lee C, Lai C, Zhuge Y, Haddad F, Fowler M, Sallam K, Wu JC
Journal Stem cell research
Publication Date 2022 Mar;59:102657
PubMed 34999423
PubMed Central PMC9250545
DOI 10.1016/j.scr.2022.102657

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