Generation of induced pluripotent stem cell lines from three individuals with autism spectrum disorder


Uncovering the molecular mechanisms of autism spectrum disorder (autism) necessitates development of relevant experimental models that are capable of recapitulating features of the clinical phenotype. Using non-integrative episomal vectors, peripheral blood mononuclear cells derived from three unrelated individuals diagnosed with autism were reprogrammed to induced pluripotent stem cells (iPSCs). The resultant lines exhibited the expected cellular morphology, karyotype, and evidence of pluripotency. These iPSCs constitute a valuable resource to support investigations of the underlying aetiology of autism. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Pugsley K, Namipashaki A, Vlahos K, Furley K, Graham A, Johnson BP, Kallady K, Kuah JY, Mohanakumar Sindhu VP, Suter A, Hawi Z, Bellgrove MA
Journal Stem cell research
Publication Date 2023 Sep;71:103170
PubMed 37494850
DOI 10.1016/j.scr.2023.103170

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