Human induced pluripotent stem cell line ZZUNEUi027-A generated from a long QT syndrome patient with a heterozygous KCNH2 (c. 128 A > G) mutant


Long QT syndrome is one of the most common hereditary arrhythmias. Mutations in KCNH2 can cause long QT syndrome type 2 (LQT2). In this study, we generated a human induced pluripotent stem cell line ZZUNEUi027-A from a LQT2 female patient with c. 128A → G in KCNH2 gene using non-integrative Sendai viral reprogramming technology. This cell line expresses pluripotency markers, exhibits a normal female karyotype (46, XX) and could differentiate into all three germ layers in vitro. ZZUNEUi027-A can serve as a cell disease model in the understanding of LQT2 pathogenesis. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Zhao J, Wang L, Zhu K, Chen X, Qin F, Li X, Dong J, Tao H
Journal Stem cell research
Publication Date 2022 Jun 7;63:102836
PubMed 35700634
DOI 10.1016/j.scr.2022.102836

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