Dynamics of a Protein Interaction Network Associated to the Aggregation of polyQ-Expanded Ataxin-1
Summary
Our study points to molecular mechanisms of SCA1 linked from both cellular and animal models and suggests drugs that could be tested to determine whether they affect the aggregation of pathogenic ATXN1 and SCA1 disease progression.
| Authors | Vagiona AC, Andrade-Navarro MA, Psomopoulos F, Petrakis S |
|---|---|
| Journal | Genes |
| Publication Date | 2020 Sep 25;11(10) |
| PubMed | 32992839 |
| PubMed Central | PMC7600199 |
| DOI | 10.3390/genes11101129 |