Dynamics of a Protein Interaction Network Associated to the Aggregation of polyQ-Expanded Ataxin-1

Summary

Our study points to molecular mechanisms of SCA1 linked from both cellular and animal models and suggests drugs that could be tested to determine whether they affect the aggregation of pathogenic ATXN1 and SCA1 disease progression.

Authors Vagiona AC, Andrade-Navarro MA, Psomopoulos F, Petrakis S
Journal Genes
Publication Date 2020 Sep 25;11(10)
PubMed 32992839
DOI 10.3390/genes11101129

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