The effects of TGF-β-induced activation and starvation of vitamin A and palmitic acid on human stem cell-derived hepatic stellate cells
Summary
scHSCs are robust models for activation studies. The loss of VA and LDs is not sufficient for scHSC activation in vitro, but may amplify the TGF-β-induced activation response. Collectively, our work provides an extensive framework for studying human HSCs in healthy and diseased conditions. © 2024. The Author(s).
| Authors | Wilhelmsen I, Combriat T, Dalmao-Fernandez A, Stokowiec J, Wang C, Olsen PA, Wik JA, Boichuk Y, Aizenshtadt A, Krauss S |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2024 Jul 23;15(1):223 |
| PubMed | 39044210 |
| PubMed Central | PMC11267759 |
| DOI | 10.1186/s13287-024-03852-8 |