UCSFi001-A-A

Cell Line

Provider

External Databases

General Information

• Shaker MR et al. Rapid and Efficient Generation of Myelinating Human Oligodendrocytes in Organoids. Frontiers in cellular neuroscience. 2021;15:631548.
• Pettinato AM et al. Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment. Cell reports. 2021 May 4;35(5):109088.
• Akter M et al. Generation of two induced pluripotent stem cell lines with heterozygous and homozygous GAG deletion in TOR1A gene from a healthy hiPSC line. Stem cell research. 2021 Oct;56:102536.
• Moita MR et al. Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis. Frontiers in cardiovascular medicine. 2022;9:1015473.
• Hommersom MP et al. Generation of induced pluripotent stem cell lines carrying monoallelic (UCSFi001-A-60) or biallelic (UCSFi001-A-61; UCSFi001-A-62) frameshift variants in CACNA1A using CRISPR/Cas9. Stem cell research. 2022 May;61:102730.
• Bulut M et al. Three-Dimensional Vessels-on-a-Chip Based on hiPSC-derived Vascular Endothelial and Smooth Muscle Cells. Current protocols. 2022 Oct;2(10):e564.
• de Graaf MNS et al. Multiplexed fluidic circuit board for controlled perfusion of 3D blood vessels-on-a-chip. Lab on a chip. 2022 Dec 20;23(1):168-181.
• Tristan CA et al. Efficient and safe single-cell cloning of human pluripotent stem cells using the CEPT cocktail. Nature protocols. 2023 Jan;18(1):58-80.
• Dyke E et al. Generation of induced pluripotent stem cell line carrying frameshift variants in NPHP1 (UCSFi001-A-68) using CRISPR/Cas9. Stem cell research. 2023 Apr;68:103053.
• Akter M et al. Generation of two induced pluripotent stem cell lines with heterozygous and homozygous amyotrophic lateral sclerosis-causing mutation P525L (c.1574C > T) in FUS gene. Stem cell research. 2023 Jun;69:103103.
• Akter M et al. Generation of two induced pluripotent stem cell lines with heterozygous and homozygous amyotrophic lateral sclerosis-causing mutation R521G (c.1561C > G) in FUS gene. Stem cell research. 2023 Jun;69:103078.
• Allan A et al. High-throughput longitudinal electrophysiology screening of mature chamber-specific hiPSC-CMs using optical mapping. iScience. 2023 Jul 21;26(7):107142.
• Bauer Lisa et al. Dissecting MPXV neurotropism and host antiviral signaling using human stem cell-based models. . 2023-08-28.
• Podleśny-Drabiniok A et al. BHLHE40/41 regulate microglia and peripheral macrophage responses associated with Alzheimer's disease and other disorders of lipid-rich tissues. Nature communications. 2024 Mar 6;15(1):2058.
• Akter M et al. Assembling a Coculture System to Prepare Highly Pure Induced Pluripotent Stem Cell-Derived Neurons at Late Maturation Stages. eNeuro. 2024 Jul;11(7).
• Neumayer G et al. A scalable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa. Nature communications. 2024 Jul 11;15(1):5834.
• Wilhelmsen I et al. The effects of TGF-β-induced activation and starvation of vitamin A and palmitic acid on human stem cell-derived hepatic stellate cells. Stem cell research & therapy. 2024 Jul 23;15(1):223.
• Durens M et al. An induced pluripotent stem cell line carrying a silencing-resistant calcium reporter allele. Stem cell research. 2024 Sep;79:103455.
• Qi L et al. Adipocyte inflammation is the primary driver of hepatic insulin resistance in a human iPSC-based microphysiological system. Nature communications. 2024 Sep 12;15(1):7991.
• Fatima N et al. Generation of induced pluripotent stem cell line (UCSFi001-A-77) carrying a biallelic frameshift variant in exon 4 of SGIP1 through CRISPR/Cas9. Stem cell research. 2024 Oct;80:103511.
• Rahimov F et al. High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene. Nature communications. 2024 Nov 6;15(1):9568.
• Amirola-Martinez M et al. Aspects of zone-like identity and holotomographic tracking of human stem cell-derived liver sinusoidal endothelial cells. Frontiers in cell and developmental biology. 2025;13:1528991.
• Galeotti AA et al. Mechanical stimulation prevents impairment of axon growth and overcompensates microtubule destabilization in cellular models of Alzheimer's disease and related Tau pathologies. Frontiers in medicine. 2025;12:1519628.
• Chidiac R et al. Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation. Stem cell reports. 2025 Feb 11;20(2):102391.
• Hommersom MP et al. CACNA1A haploinsufficiency leads to reduced synaptic function and increased intrinsic excitability. Brain : a journal of neurology. 2025 Apr 3;148(4):1286-1301.
• Wiegering A et al. A differential requirement for ciliary transition zone proteins in human and mouse neural progenitor fate specification. Nature communications. 2025 Apr 5;16(1):3258.
• Gehr NL et al. Neurofilament light chain as a marker for neuronal damage: integrating in vitro studies and clinical findings in patients with oxaliplatin-induced neuropathy. Cancer chemotherapy and pharmacology. 2025 Apr 10;95(1):53.
• Binan L et al. Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits. Cell. 2025 Apr 17;188(8):2141-2158.e18.
• Liu Z et al. HAND1, partially mediated through ape-specific LTR binding, is essential for human extra-embryonic mesenchyme derivation from iPSCs. Cell reports. 2025 Apr 22;44(4):115568.
• Xu G et al. Macrophage-augmented intestinal organoids model virus-host interactions in enteric viral diseases and facilitate therapeutic development. Nature communications. 2025 May 14;16(1):4475.
• Skowronek D et al. High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins. Angiogenesis. 2025 Jun 6;28(3):32.
• Shin YJ et al. A4GALT-targeting siRNA lipid nanoparticles ameliorate Fabry disease phenotype: Greater efficacy in endothelial cells than in podocytes. Molecular therapy. Nucleic acids. 2025 Jun 10;36(2):102573.
• Kumari P et al. Identification of functional non-coding variants associated with orofacial cleft. Nature communications. 2025 Jul 16;16(1):6545.
• Al Kabbani MA et al. Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice. Neural regeneration research. 2025 Aug 1;20(8):2348-2360.
• Foerster LC et al. Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression. Nature communications. 2025 Aug 6;16(1):7250.
• Mella J et al. C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin. eLife. 2025 Aug 28;14.
• Kyndiah A et al. Non-invasive action potential recordings using printed electrolyte-gated polymer field-effect transistors. Nature communications. 2025 Aug 31;16(1):8143.
• Majd H et al. Engrafted nitrergic neurons derived from hPSCs improve gut dysmotility in mice. Nature. 2025 Sep;645(8079):158-167.
• Apsley EJ et al. Cerebellar organoids model cell type-specific FOXP2 expression during human cerebellar development. Disease models & mechanisms. 2025 Nov 1;18(11).
• Anglen T et al. A gene regulatory element modulates myosin expression and controls cardiomyocyte response to stress. Genome research. 2025 Nov 3;35(11):2418-2432.
• Arana S et al. Reduced Cas9 transgene silencing by incorporation of intron sequences. Nature communications. 2025 Nov 27;16(1):10656.
• Vital CM et al. Integrative Proteomics of Extracellular Vesicles from hiPSC-Derived Cardiac Organoids Reveals Heart Tissue-like Molecular Representativity. International journal of molecular sciences. 2026 Jan 19;27(2).
• Benavides FFW et al. Non-polio enterovirus infection and electrophysiological changes in human iPSC-derived neural networks. EBioMedicine. 2026 Mar 12;126:106201.
• (unknown author). Quinone reductase 2 reads H3 serotonylation to support neuronal maturation. bioRxiv. 2026-03-19.
• Senoo N et al. Disturbed mitochondrial maturation in cardiolipin remodeling-deficient cardiomyocytes. iScience. 2026 Mar 20;29(3):115111.

• UCSFi001-A

General Donor Information

Phenotype and Disease related information (Donor)

Other Genotyping (Donor)

• UCSFi001-A
• SCVIi038-A
• SUSMi008-A
• SUSMi008-B
• SCTCi019-A
• SCTCi019-B
• AICSi001-B

General

Reprogramming method

Vector free reprogramming

Other

Karyotyping (Cell Line)

Other Genotyping (Cell Line)