Neurofilament light chain as in vitro and clinical biomarker of vincristine-induced peripheral neuropathy
Summary
Vincristine causes concentration-dependent NfL release in vitro, and sNfL levels increase during vincristine treatment. Further studies are needed to investigate sNfL's potential as a biomarker of VIPN in children with ALL. © 2026 The Author(s). British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
| Authors | Pontoppidan PEL, Vase CB, Mortensen C, Andres-Jensen L, Olsen DA, Madsen JS, Schmiegelow K, Mathiasen R, Stage TB |
|---|---|
| Journal | British journal of clinical pharmacology |
| Publication Date | 2026 Sep;92(9):3180-3190 |
| PubMed | 42162566 |
| PubMed Central | PMC13519789 |
| DOI | 10.1002/bcp.70599 |