Generation and Differentiation of Induced Pluripotent Stem Cells from Mononuclear Cells in An Age-Related Macular Degeneration Patient


A high quality iPSCs could be established from the PBMCs obtained from elderly AMD patient. The AMDiPSC displayed complete pluripotency, enabling for scientific study, disease modeling, pharmacological testing, and therapeutic applications in personalized medicine. Collectively, we successfully differentiated the iPSCs into RPE with native RPE characteristics, which might provide potential regenerative treatments for AMD patients.

Authors Wang T, Liu J, Chen J, Qin B
Journal Cell journal
Publication Date 2022 Dec 1;24(12):764-773
PubMed 36527349
PubMed Central PMC9790072
DOI 10.22074/cellj.2022.557559.1072

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