Generation of an induced pluripotent stem cell (iPSC) line (BBANTWi009-A) from a Meester-Loeys syndrome patient carrying a BGN mutation
Summary
Meester-Loeys syndrome (MRLS) is an X-linked syndromic form of thoracic aortic aneurysm and dissection. Here, we report an iPSC line (BBANTWi009-A) of a boy carrying a hemizygous BGN mutation (chrX:153502980-153530518del, GRCh38) causing MRLS. iPSCs were generated from dermal fibroblasts by reprogramming with the Cytotune®-iPS 2.0 Sendai Reprogramming Kit (Invitrogen). The generated iPSCs showed a normal karyotype, expressed pluripotency markers, were differentiated into the three germ layers and carried the original genotype. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | De Kinderen P, Rabaut L, Hebert A, Ponsaerts P, Perik M, Meester JAN |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2023 Feb;66:103009 |
| PubMed | 36599284 |
| DOI | 10.1016/j.scr.2022.103009 |