Generation of an induced pluripotent stem cell (iPSC) line (BBANTWi009-A) from a Meester-Loeys syndrome patient carrying a BGN mutation


Meester-Loeys syndrome (MRLS) is an X-linked syndromic form of thoracic aortic aneurysm and dissection. Here, we report an iPSC line (BBANTWi009-A) of a boy carrying a hemizygous BGN mutation (chrX:153502980-153530518del, GRCh38) causing MRLS. iPSCs were generated from dermal fibroblasts by reprogramming with the Cytotune®-iPS 2.0 Sendai Reprogramming Kit (Invitrogen). The generated iPSCs showed a normal karyotype, expressed pluripotency markers, were differentiated into the three germ layers and carried the original genotype. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors De Kinderen P, Rabaut L, Hebert A, Ponsaerts P, Perik M, Meester JAN
Journal Stem cell research
Publication Date 2023 Feb;66:103009
PubMed 36599284
DOI 10.1016/j.scr.2022.103009

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