Generation and characterisation of four multiple sclerosis iPSC lines from a single family


Multiple sclerosis (MS) is a complex neuroinflammatory/degenerative disease of the central nervous system (CNS) that results in the formation of demyelinated lesions and axon degeneration. MS aetiology is complex, with genetics estimated to account for ∼48% of MS risk (International Multiple Sclerosis Genetics Consortium, 2019). Despite this, families with a high incidence of MS are rare. We have generated four induced pluripotent stem cell (iPSC) lines from individuals with relapsing-remitting and secondary progressive MS within a single family. The generation of disease-specific iPSC lines from multiple members of a single family will facilitate MS genetic and functional studies. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Fortune AJ, Taylor BV, Charlesworth JC, Burdon KP, Blackburn NB, Fletcher JL, Mehta A, Young KM
Journal Stem cell research
Publication Date 2022 Jul;62:102828
PubMed 35679759
DOI 10.1016/j.scr.2022.102828

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