Generation and characterisation of four multiple sclerosis iPSC lines from a single family
Summary
Multiple sclerosis (MS) is a complex neuroinflammatory/degenerative disease of the central nervous system (CNS) that results in the formation of demyelinated lesions and axon degeneration. MS aetiology is complex, with genetics estimated to account for ∼48% of MS risk (International Multiple Sclerosis Genetics Consortium, 2019). Despite this, families with a high incidence of MS are rare. We have generated four induced pluripotent stem cell (iPSC) lines from individuals with relapsing-remitting and secondary progressive MS within a single family. The generation of disease-specific iPSC lines from multiple members of a single family will facilitate MS genetic and functional studies. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Fortune AJ, Taylor BV, Charlesworth JC, Burdon KP, Blackburn NB, Fletcher JL, Mehta A, Young KM |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Jul;62:102828 |
| PubMed | 35679759 |
| DOI | 10.1016/j.scr.2022.102828 |