Generation of induced pluripotent stem cell line (XWHNi003-A) from a female with APOE gene mutation
Summary
Apolipoprotein E (APOE)is the gene with greatest genetic risk for Alzheimer's disease (AD). We successfully established a human induced pluripotent stem cell(iPSC) line from a woman mutated by APOE gene. The cell line was isolated from this woman's peripheral blood mononuclear cells using a non-integrated Sendai virus, which retained the original genotype, showed a normal karyotype, highly expressed pluripotent markers and could differentiate into three germ layers. Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Gong J, Li S, Sun W, Wang P, Han X, Xu C, Chen Y, Yang Y, Luan H, Li R, Wen B, Lv S, Chen R, Guo J, Wei C |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Sep;79:103501 |
| PubMed | 39029293 |
| DOI | 10.1016/j.scr.2024.103501 |