Generation of a transgene-free induced pluripotent stem cell line (SMBCi011-A) from a patient with Prader-Willi syndrome
Summary
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by deficiency of paternal gene expression in the 15q11.2-q13 chromosome imprinted region. Hyperphagia and dysgnosia are typical clinical features in the early-childhood of patient. We generated an induced pluripotent stem cell (iPSC) line SMBCi011-A from a 6 years old male PWS patient, the line expressed pluripotent signs and had ability to differentiate into three germ layers in vivo. Copyright © 2022. Published by Elsevier B.V.
| Authors | Jia G, Cui Y, Shi L, Luan J, Wang J, Han J |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Apr;60:102695 |
| PubMed | 35203049 |
| DOI | 10.1016/j.scr.2022.102695 |