Generation of a transgene-free induced pluripotent stem cell line (SMBCi011-A) from a patient with Prader-Willi syndrome


Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by deficiency of paternal gene expression in the 15q11.2-q13 chromosome imprinted region. Hyperphagia and dysgnosia are typical clinical features in the early-childhood of patient. We generated an induced pluripotent stem cell (iPSC) line SMBCi011-A from a 6 years old male PWS patient, the line expressed pluripotent signs and had ability to differentiate into three germ layers in vivo. Copyright © 2022. Published by Elsevier B.V.

Authors Jia G, Cui Y, Shi L, Luan J, Wang J, Han J
Journal Stem cell research
Publication Date 2022 Apr;60:102695
PubMed 35203049
DOI 10.1016/j.scr.2022.102695

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