Generation of 6 lines of human pluripotent stem cells from hypertensive patients and 3 lines of human pluripotent stem cell from normotensive patients


Hypertension is a complex multifactorial disease characterized by a chronic increase of arterial pressure. Ninety percent of the cases are idiopathic and thus classified as essential hypertension. Uncontrolled arterial pressure has devasting consequences including cardiac insufficiency, stroke, dementia, chronic renal disease, ischemic heart disease and death. The hiPSC lines described here from six hypertensive patients and three controls were characterized according to established criteria and were shown to maintain pluripotency, differentiation into the three germ layers and genomic integrity. These cell lines can contribute to the understanding of the molecular mechanisms involved in hypertension in different cell types. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Sarafian R, Morato-Marques M, Borsoi J, Tófoli-Araújo F, Pinheiro M, Medina-Armenteros Y, Lotufo PA, Bensenor IM, Pereira LV
Journal Stem cell research
Publication Date 2021 May;53:102384
PubMed 34088012
DOI 10.1016/j.scr.2021.102384

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