Generation of three induced pluripotent stem cell lines from a Parkinson's disease patient with mutant PARKIN (p. C253Y)


Parkinson's disease (PD) is one of the most common neurodegenerative disorders and is characterized by the progressive degeneration of dopaminergic (DA) neurons in the substantia nigra. Loss of function mutations in PARK2 cause familial PD in an autosomal recessive manner. PARK2 encodes an E3 ubiquitin ligase that is involved in regulation of mitochondrial homeostasis. However, the mechanistic links between PARK2 mutations and dopaminergic neuron degeneration are unclear. Here, we have generated three patient-derived induced pluripotent stem cell (iPSC) lines from the same donor with mutant PARKIN (p. C253Y). These well characterized cell lines will facilitate the study of PARKIN function in disease relevant cell types in vitro. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Tariq M, Liu H, Ibañez DP, Li Y, Chen S, Jiang M, Fan W, Zhao P, Luo Z, Wang D, Kanwal S
Journal Stem cell research
Publication Date 2020 May;45:101822
PubMed 32387897
DOI 10.1016/j.scr.2020.101822

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