Amyloid beta accumulations and enhanced neuronal differentiation in cerebral organoids of Dutch-type cerebral amyloid angiopathy patients
Summary
These results illustrate the potential of cerebral organoids as in vitro disease model of D-CAA that can be used to understand disease mechanisms of D-CAA and can serve as therapeutic intervention platform for various Aβ-related disorders. Copyright © 2023 Daoutsali, Pepers, Stamatakis, van der Graaf, Terwindt, Parfitt, Buijsen and van Roon-Mom.
| Authors | Daoutsali E, Pepers BA, Stamatakis S, van der Graaf LM, Terwindt GM, Parfitt DA, Buijsen RAM, van Roon-Mom WMC |
|---|---|
| Journal | Frontiers in aging neuroscience |
| Publication Date | 2022;14:1048584 |
| PubMed | 36733499 |
| PubMed Central | PMC9887998 |
| DOI | 10.3389/fnagi.2022.1048584 |