Induced pluripotent stem cells derived from one 70-years-old male donor with the APOE-ε4/ε4 alleles


Apolipoprotein E (ApoE) is a lipid-binding protein with ε2, ε3, and ε4 allelic variants in human. The ε4 isoform (ApoE4) is the strongest genetic risk factor for the late-onset form of Alzheimer's disease (AD), and is also associated with multiple neurological disorders, multiple sclerosis, and cerebrovascular disease. Here, induced pluripotent stem cells were derived from the peripheral blood mononuclear cells of a 70-year-old male donor with APOE-ε4/ε4 alleles background to explore pathogenesis and screen potential treatment methods in neurodegenerative diseases. In the newly-developed induced pluripotent stem cell line, the pluripotent markers were well expressed. In addition, the generated cells displayed a normal karyotype and have differentiation potential. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Wang J, Liu X, Du X, Ma Z, Liu B, Guo R, Feng B, Ma J, Cui H
Journal Stem cell research
Publication Date 2021 May;53:102395
PubMed 34088020
DOI 10.1016/j.scr.2021.102395

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