Establishment of three human induced pluripotent stem cell lines from a type 1 diabetic family harboring sequence variants associated with autoimmunity


Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing β cells. Genetic studies have identified > 60 T1D risk loci that harbor genes with disease-causative alleles. However, determining the biological effects of such loci is often difficult due to limited tissue availability. Disease-specific human induced pluripotent stem cells (hiPSCs) are a valuable resource for modeling T1D pathogenesis. In particular, families with complete disease penetrance offer an opportunity to further dissect T1D risk loci. Here, we describe the generation of three hiPSC lines from a T1D family with sequence variants associated with autoimmunity. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Chu EP, Lin CH, Cho CH, Cheng IF, Kuo TC, Chen RY, Liao CN, Cheng JC, Tsai JI, Wang PC, Chang SJ, Shen CN
Journal Stem cell research
Publication Date 2020 Dec;49:102029
PubMed 33096384
DOI 10.1016/j.scr.2020.102029

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