Generation and characterization of human induced pluripotent stem cells (iPSCs) from three individuals without age-related macular degeneration


Age-related macular degeneration (AMD) is a major cause of vision loss among the elderly in the Western world. AMD is multifactorial eye disease with a strong genetic contribution. Here, we report the generation and characterization of induced pluripotent stem cells (iPSCs) derived from peripheral blood mononuclear cells of three individuals above 70 years of age without AMD. These cell lines were generated to serve as control lines for cellular studies investigating the disease mechanisms and developing therapeutic interventions for AMD. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Koolen L, Gagliardi G, Ten Brink SCA, de Breuk A, Heesterbeek TJ, Hoyng CB, Albert S, den Hollander AI
Journal Stem cell research
Publication Date 2022 Apr;60:102670
PubMed 35078129
DOI 10.1016/j.scr.2022.102670

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