Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi005-A) from a Wilson's disease patient harboring a homozygous Pro992Leu mutation in ATP7B gene


Using non-integrative reprogramming method, a human induced pluripotent stem cell (iPSC) line, ZZUNEUi005-A, was generated from a 36-year-old male patient with Wilson's disease, carrying a homozygous Pro992Leu mutation in the ATP7B gene. This cell line shows pluripotency both in vitro and in vivo and has a normal karyotype. Furthermore, we showed that this iPSC line could be differentiated into neural and hepatocyte-like cells. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Wei L, Zhang J, Chen D, Feng L, Wu C, Wang R, Li X
Journal Stem cell research
Publication Date 2020 Jul 15;47:101909
PubMed 32745714
DOI 10.1016/j.scr.2020.101909

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