Proteomic profiling of human embryonic stem cell-derived microvesicles reveals a risk of transfer of proteins of bovine and mouse origin


These findings indicate that MV represent a mechanism by which hESC communicate; however, they also serve as potential carriers of immunogenic and pathogenic compounds acquired from environment. Our results highlight a potential danger regarding the use of hESC that have previously been exposed to animal proteins and cells.

Authors Kubikova I, Konecna H, Sedo O, Zdrahal Z, Rehulka P, Hribkova H, Rehulkova H, Hampl A, Chmelik J, Dvorak P
Journal Cytotherapy
Publication Date 2009;11(3):330-40, 1 p following 340
PubMed 19401887
DOI 10.1080/14653240802595531

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